Spyre Therapeutics, Inc SYRE

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Spyre Therapeutics, Inc. - Common Stock · Company · Nasdaq · Healthcare / Biotechnology

Paper trade (simulated — no real money)

Fill: USD 90.3300 · FX 1 USD = 1.277900 SGD · about SGD 115.4327 per unit

Sign in to practise with simulated trades before investing real money. USD fills are converted into the SGD portfolio at the displayed rate.

Announcement types: (default: consequential filings)
Results & current reports
Capital markets
Ownership & governance

USD closing-price chart (daily close from yfinance · Last year)

USD 23.37 → 90.33 · 286.5%
108.92065.55022.180 1,2 3 4,5,6 7,8 9,10,11 12,13 14,15 16 17 18 19 20,21 22 23 24 25 26 Oct 25Jan 26Apr 26Jul 26Oct 26

Numbered dotted lines mark the filtered filings under Announcement Events below.

Price & SEC Filing History 24 Oct 2025 — 25 Oct 2026 (Last year)

Daily Nasdaq prices are sourced from yfinance. Yellow highlighting marks an intraday rise or a gap up between adjacent trading sessions. SEC acceptance times are converted to US Eastern time: pre-market filings appear below that day’s OHLCV row; filings accepted after the 09:30 ET open appear above it. The SEC does not publish an exact first-public-availability timestamp, so acceptance time is the best available proxy.

Weekend
Weekend
90.7050 91.9000 88.6900 90.3300 502,891
92.9500 94.5650 91.2700 92.3300 802,900
92.7800 95.1700 92.3150 92.9500 1,153,100
85.1200 93.2200 85.0750 91.4000 1,708,500
82.2900 86.0500 80.9400 84.7200 1,272,000
Weekend
Weekend
80.2100 80.5200 78.1250 79.9000 1,273,300
76.8700 80.8800 76.8700 80.1000 1,148,000
80.1300 82.4500 77.9500 78.6300 1,624,600
85.1200 85.3200 80.4500 80.4500 1,441,000
86.3000 86.6200 84.2100 85.9000 873,900
Weekend
Weekend
79.9000 86.2200 78.7300 85.6900 1,116,400
79.5800 80.9100 77.0500 79.9000 2,326,700
26 · 8-K After market open · 12:00 ET 8-K ↗
78.9100 82.2200 78.0000 80.8500 2,719,300
25 · 424B5 After-hours · 20:41 ET 424B5 ↗
92.0800 92.0800 79.3600 80.1100 4,252,300
24 · 424B5 After-hours · 20:10 ET 424B5 ↗
93.0200 95.0100 89.4900 92.7200 642,800
Weekend
Weekend
91.1600 95.2700 90.4800 93.1900 1,235,000
89.1300 94.0600 87.2470 89.9300 1,662,600
88.6400 95.0800 88.0000 89.0300 2,096,000
85.0900 86.6400 83.2550 84.7200 1,053,200
84.7200 87.1230 84.0000 85.7900 1,045,400
Weekend
Weekend
88.1000 88.1000 85.6300 85.6900 560,100
87.4600 87.4600 82.9300 87.0900 1,729,600
91.5600 91.5600 86.3000 88.1700 918,800
91.5300 93.5800 89.9000 91.9700 1,223,400
91.0700 94.0550 89.6500 92.0300 1,448,700
Weekend
Weekend
92.8200 93.3400 89.8500 90.2500 3,357,100
92.8600 95.1900 91.1400 92.6800 1,438,900
91.3800 93.0650 90.4800 91.1700 1,257,600
90.8200 91.0700 88.4700 90.9500 858,500
90.2100 91.4030 89.4300 90.8000 1,101,200
Weekend
Weekend
90.0000 91.4050 87.8900 90.6000 886,100
85.5600 88.7200 85.2600 88.7100 902,400
88.0700 89.5700 86.8500 86.9300 1,005,800
85.0020 92.1000 85.0000 90.7900 1,248,800
23 · 8-K Pre-market · 08:01 ET 8-K ↗
No trading
Weekend
Weekend
86.4500 89.1800 84.6800 88.9800 803,800
86.7100 87.9000 85.7750 87.2500 1,054,200
88.0500 90.1800 84.0000 87.0500 1,361,500
87.0600 90.0000 85.0000 88.5000 1,429,000
89.1500 90.9650 86.4000 89.3300 1,913,200
Weekend
Weekend
91.7500 93.3900 89.4500 90.3600 1,266,500
93.6100 94.9450 91.2500 93.6150 1,165,300
92.4100 96.2200 90.6000 93.6050 3,114,200
22 · 8-K After-hours · 16:04 ET 8-K ↗
109.0200 110.1500 106.9400 107.3600 923,600
106.4900 108.0200 104.9400 106.6500 640,600
Weekend
Weekend
108.8500 110.0000 105.7100 106.4900 1,014,900
106.6000 108.1800 104.5600 107.7900 700,600
110.0000 110.1750 104.1700 108.9200 1,166,000
102.4600 108.6200 101.4390 107.8200 949,400
102.9400 104.9600 102.2600 104.6000 891,500
Weekend
Weekend
101.2100 104.1300 95.6100 103.6300 559,500
101.0000 103.8400 100.9000 101.8500 525,400
105.0550 105.0550 99.0000 104.0900 909,600
105.3300 105.4400 99.8400 102.7400 931,700
106.1900 107.0000 103.3300 105.3300 822,700
Weekend
Weekend
106.0100 106.6700 103.6400 104.9100 526,600
102.3900 106.7500 101.6400 103.4200 454,500
104.9400 108.1400 100.8800 104.3500 1,037,400
21 · 8-K After-hours · 16:05 ET 8-K ↗ 20 · 10-Q After-hours · 16:02 ET 10-Q ↗
98.2700 105.2500 97.0300 104.9400 832,000
97.1500 99.5760 92.7100 94.9300 898,400
Weekend
Weekend
100.5800 100.5800 95.2700 98.3300 621,700
98.2600 101.8750 97.3900 101.5000 851,500
99.3800 100.9850 94.5200 97.8700 1,216,600
97.1900 100.9300 92.3700 99.9600 1,512,800
102.0100 105.0500 98.8700 100.0400 669,300
Weekend
Weekend
100.5600 103.5700 98.7900 102.1300 812,800
97.0600 100.3500 97.0000 99.9900 634,800
102.3900 102.3900 99.0650 99.1700 596,100
99.0700 103.3100 98.5000 102.7000 776,500
101.0150 102.9200 97.2800 97.3300 750,200
Weekend
Weekend
94.2600 101.3600 92.3700 100.2300 1,091,400
103.3200 103.3200 93.3700 94.1200 1,370,600
100.2100 102.5800 95.1350 102.0700 1,520,400
96.0600 105.0900 94.9550 98.9500 2,776,000
95.7200 96.8150 92.6700 93.7300 1,038,800
Weekend
Weekend
98.7500 99.3400 94.1340 97.7400 779,200
96.3600 99.0000 96.1100 98.7500 1,329,800
94.3600 95.5900 90.6450 95.4000 1,240,500
90.0000 95.1550 86.6000 94.2300 1,305,800
87.2700 91.8900 86.6100 88.7400 1,388,900
Weekend
Weekend
No trading
89.1100 89.6900 85.1700 86.6300 973,900
88.2100 89.0150 86.4100 88.8900 1,682,200
90.3000 91.9550 88.6000 88.7800 1,467,300
86.5550 90.9000 84.8100 90.1600 2,014,800
Weekend
Weekend
19 · S-3ASR After-hours · 16:05 ET S-3ASR ↗
91.0000 91.0000 85.9700 87.8900 4,441,200
86.4600 89.6700 84.9600 88.6700 2,108,900
83.2200 88.1500 81.6500 86.2400 4,044,400
97.7200 102.0600 95.3100 97.0500 2,640,300
95.0000 101.7050 95.0000 100.3200 2,805,300
Weekend
Weekend
No trading
89.5500 90.9900 86.1800 88.3400 2,420,400
84.9700 88.0300 83.1700 87.4900 1,537,200
83.5400 84.9250 81.7000 83.4100 1,337,100
81.5700 84.6900 80.7900 83.5800 1,156,400
18 · 8-K Pre-market · 08:01 ET 8-K ↗
Weekend
Weekend
81.0900 84.4300 80.7200 80.7900 958,600
75.7400 81.6200 75.3500 80.7700 1,267,900
77.1800 79.5200 74.7900 75.0800 981,300
73.6500 77.1100 70.8900 76.4400 1,593,100
75.5300 76.3100 71.1100 72.0000 1,036,000
Weekend
Weekend
77.7700 78.9000 73.0600 73.6500 1,479,800
73.5700 79.5400 73.2900 78.4800 1,118,900
70.3250 76.1050 69.8150 73.5200 1,679,700
69.9900 70.5000 68.5000 69.1600 814,300
17 · 8-K After-hours · 16:01 ET 8-K ↗
72.3850 73.2100 68.8500 70.5400 921,800
Weekend
Weekend
16 · 8-K After-hours · 16:45 ET 8-K ↗
72.1100 74.3600 71.5100 73.5000 1,113,800
72.3600 73.3300 71.0750 72.1100 429,000
73.9900 74.3500 72.2400 72.5100 558,000
74.8700 76.1200 72.1100 73.6500 478,400
No trading
Weekend
Weekend
75.3400 75.6300 73.1100 74.0500 574,900
70.8900 74.4300 70.1800 74.3200 738,600
68.6400 72.4700 67.8800 71.9200 1,088,200
70.0800 70.0800 64.6700 66.6200 1,385,700
75.0800 75.6500 69.0100 70.0800 1,079,100
Weekend
Weekend
77.0800 77.0800 72.5400 74.9200 1,958,700
76.5100 77.7600 74.4900 75.6500 449,800
75.6900 78.0000 73.4800 76.3100 776,700
77.0000 77.2000 73.2200 75.0400 1,760,400
75.1500 78.8000 74.3900 76.4300 1,333,300
Weekend
Weekend
73.1000 75.9100 72.4000 75.0450 840,600
73.5800 74.5100 71.1300 73.1000 923,500
70.6800 73.5100 70.1050 73.0000 711,500
70.6450 73.2150 70.2100 71.0100 2,010,900
15 · 8-K Pre-market · 08:05 ET 8-K ↗ 14 · 10-Q Pre-market · 08:00 ET 10-Q ↗
68.2600 71.6700 67.1800 69.1300 1,009,000
Weekend
Weekend
74.0900 76.0000 69.1700 69.4200 1,463,700
72.3300 75.0000 72.0800 74.4500 1,044,300
68.2500 73.6150 67.5000 71.8900 1,808,200
72.1000 73.9550 68.2000 68.6300 1,070,300
69.5300 72.3000 69.5300 71.9000 687,100
Weekend
Weekend
69.8300 72.0700 68.4320 69.6700 601,100
73.0100 73.7300 68.3250 69.2400 693,100
72.9600 74.3500 71.7100 73.0000 1,070,600
73.3900 74.8400 69.9500 71.2700 1,354,800
72.2000 74.6800 72.0300 73.3900 915,700
Weekend
Weekend
70.3200 74.6000 70.2100 73.0100 2,126,500
13 · 8-K After-hours · 16:15 ET 8-K ↗
68.9400 70.3000 66.8800 69.7000 2,194,700
12 · 424B5 Next filing day · accepted 15 Apr, 17:42 ET 424B5 ↗
67.7500 69.4500 64.6000 68.9900 4,196,700
67.6800 67.6800 60.7500 64.0100 1,672,900
11 · 424B5 After-hours · 17:26 ET 424B5 ↗ 10 · 8-K After-hours · 16:29 ET 8-K ↗
67.0000 75.0000 59.0200 63.2700 5,361,100
9 · 8-K Pre-market · 07:46 ET 8-K ↗
Weekend
Weekend
8 · DEFA14A After-hours · 16:05 ET DEFA14A ↗ 7 · DEF 14A After-hours · 16:01 ET DEF 14A ↗
51.4000 52.9800 50.8500 51.2900 499,300
51.6300 52.7700 51.2000 51.7700 587,500
52.7000 54.3900 50.3900 51.9800 1,043,900
48.9700 51.2600 48.8250 51.2000 799,500
47.5800 49.8500 46.7900 48.9800 791,700
Weekend
Weekend
No trading
47.1700 48.4000 46.2650 47.5800 438,000
50.3250 51.0000 48.6400 48.9000 890,700
46.2800 51.0600 46.2800 50.4400 1,043,700
47.7500 48.4700 44.8000 45.4200 712,500
Weekend
Weekend
46.9300 47.9500 46.7000 47.3100 832,300
45.3900 49.3050 45.2300 47.5200 1,332,500
42.9300 45.7900 42.6800 45.6800 668,000
41.7800 42.7600 40.9100 42.2200 724,500
42.0200 44.0800 41.7300 42.7600 779,400
Weekend
Weekend
42.1100 43.2200 41.1600 41.2500 1,410,500
42.9800 43.2200 41.7400 42.3100 628,400
44.2800 44.2800 42.3600 43.0600 798,400
44.2500 45.3900 43.7700 43.9500 844,100
40.7300 44.4900 40.7300 44.0700 1,246,100
Weekend
Weekend
40.9200 42.4000 39.0000 39.8900 844,900
40.2200 40.7500 39.2000 40.4100 711,400
41.2500 42.6100 41.0550 41.5000 571,200
41.0900 42.9300 41.0900 41.5700 650,800
39.7500 41.8800 39.2100 41.0700 890,300
Weekend
Weekend
39.9900 40.5850 38.3600 40.1500 567,600
40.3400 41.5000 39.9000 40.5900 638,500
40.1400 42.5800 40.0700 41.0000 725,000
40.9900 41.8500 39.9800 40.0700 921,700
41.2700 42.9300 40.7400 42.4900 742,300
Weekend
Weekend
42.4200 43.8000 42.2650 43.0100 695,200
43.7900 44.2600 42.0270 43.1500 534,800
44.1800 44.8800 43.4300 43.8800 521,600
44.1700 44.8100 43.0500 43.4500 636,400
43.0100 45.7600 42.2600 44.1800 1,095,800
Weekend
Weekend
37.8200 43.5600 37.8100 43.2100 2,278,400
6 · 8-K After-hours · 16:05 ET 8-K ↗ 5 · 10-K After-hours · 16:01 ET 10-K ↗ 4 · S-3 After-hours · 16:33 ET S-3 ↗
36.6600 38.1600 35.9300 37.8100 803,900
36.0500 37.6600 35.9300 36.6000 702,200
36.3900 37.2200 34.9600 35.9500 681,100
No trading
Weekend
Weekend
35.0200 37.9800 35.0200 36.6300 1,320,100
33.9800 34.9200 33.5900 34.8400 623,200
33.5900 34.1300 32.3500 33.9200 361,800
34.2800 34.9300 33.1900 33.5600 648,400
35.1200 35.5750 33.7800 33.9600 679,500
Weekend
Weekend
33.7700 35.2100 33.1600 35.1200 790,500
31.8500 33.6700 31.3980 32.9400 972,800
33.5700 34.0700 30.9200 32.0700 408,700
32.7700 33.9600 32.6600 33.2900 453,700
31.7600 33.3500 30.9900 32.7500 442,800
Weekend
Weekend
33.2700 33.6500 31.6000 31.9800 535,800
32.9600 33.7650 32.8300 33.5800 570,900
33.4500 34.0300 32.4870 33.1400 318,600
32.3100 33.7700 32.3100 33.3600 359,900
31.5220 33.0800 31.5220 32.2900 410,700
Weekend
Weekend
33.0500 34.4700 31.7750 32.0350 407,700
33.8700 35.0650 33.8200 34.0900 847,500
33.6800 34.5100 33.3300 33.9900 512,300
32.3400 33.9150 31.6200 33.7300 597,000
No trading
Weekend
Weekend
33.2000 34.0000 32.4000 33.2400 439,300
33.2600 34.1700 32.5700 33.0900 812,300
31.5300 34.2100 31.5300 33.1600 1,037,300
32.9500 33.7050 31.0300 31.5300 657,000
30.6000 33.1000 30.0000 32.8000 581,600
3 · 8-K Pre-market · 09:00 ET 8-K ↗
Weekend
Weekend
30.4600 31.4500 30.3550 30.6100 456,100
30.4200 30.7050 29.6000 30.1400 569,300
30.4450 31.6900 30.2080 31.0500 588,700
29.9200 30.3900 29.4320 30.3300 752,800
30.4900 30.5500 28.0000 29.9600 987,200
Weekend
Weekend
32.7600 33.3100 30.1100 30.5800 888,700
No trading
31.7800 32.8400 31.5160 32.7600 533,200
32.4500 32.5300 31.5000 31.8800 392,900
32.7700 33.2200 32.0500 32.5600 348,500
Weekend
Weekend
33.0000 33.0250 32.3000 32.9400 307,900
No trading
33.3800 34.1000 32.7900 33.0500 292,000
33.8400 34.4400 32.9600 33.2300 518,300
32.9300 34.5150 32.5000 34.2000 1,181,100
Weekend
Weekend
33.8200 34.8400 33.2150 33.4000 4,010,100
33.6600 34.2400 32.8800 33.4700 642,200
33.5100 34.3160 32.7600 33.0600 493,500
33.0000 33.5200 32.2600 32.9700 519,800
33.9300 34.9600 33.1500 33.3400 729,400
Weekend
Weekend
34.3600 35.1700 33.2400 33.6200 731,700
34.7700 35.3100 34.1700 34.3600 666,800
33.7000 34.9350 33.5100 34.6600 765,700
34.4800 34.9800 33.5200 33.6800 1,123,800
33.9500 34.9600 33.4500 34.6300 1,178,600
Weekend
Weekend
33.5600 34.0600 33.0000 33.4500 553,500
32.1800 34.5400 31.4400 33.5100 938,200
28.8500 32.2550 28.5000 32.2000 1,314,300
28.8500 29.8400 28.1600 28.4000 643,600
30.5500 30.5500 28.4500 28.6600 867,300
Weekend
Weekend
30.0000 30.2100 29.7500 30.0000 562,700
No trading
29.2100 29.7800 28.7100 29.7500 503,100
26.7300 29.4950 26.6400 29.2000 630,500
24.9500 27.2100 24.5800 26.9700 962,600
Weekend
Weekend
23.2900 24.9700 23.0100 24.2600 496,300
24.7700 25.4200 23.2200 23.4700 627,700
24.5200 25.0700 23.6900 24.3000 586,700
24.1800 24.7000 23.7500 24.1000 493,700
23.4700 25.0200 23.0300 24.3600 724,300
Weekend
Weekend
22.2600 24.5000 22.1260 23.5000 543,600
23.1300 23.5700 22.4700 22.6300 514,600
23.3900 24.1900 22.9100 23.4300 611,400
22.2100 23.6750 21.6300 23.3500 533,900
22.9300 23.0000 21.9600 22.1800 416,600
Weekend
Weekend
21.8800 22.5400 21.1450 22.5200 569,200
22.5300 22.9850 21.8800 22.3900 504,700
23.3700 23.5000 22.0300 22.8500 813,200
2 · 8-K After-hours · 16:11 ET 8-K ↗ 1 · 10-Q After-hours · 16:01 ET 10-Q ↗
23.2900 23.5600 22.8700 22.9800 696,300
23.9500 24.4500 22.4200 23.7800 1,045,800
Weekend
Weekend
24.1000 24.5900 23.6500 24.4600 683,300
23.7900 24.6800 23.7800 24.2600 488,400
24.4800 25.0050 23.5200 23.8300 1,078,000
24.3000 25.0550 24.2900 24.6400 751,100
24.0100 25.0000 23.6500 24.5700 1,270,000
Weekend
Weekend
22.5600 23.5900 22.3500 23.3700 700,700

Announcement Events

Each title opens the filing on the SEC website. Registered users can summarise the filing and up to seven relevant exhibits linked within the same SEC submission.

26 8-K 8-K (opens SEC filing in a new tab) After market open · 12:00 ET Summarise
25 424B5 424B5 (opens SEC filing in a new tab) After-hours · 20:41 ET Summarise
24 424B5 424B5 (opens SEC filing in a new tab) After-hours · 20:10 ET Summarise
23 8-K 8-K (opens SEC filing in a new tab) Pre-market · 08:01 ET Summarise
22 8-K 8-K (opens SEC filing in a new tab) After-hours · 16:04 ET Summarise
21 8-K 8-K (opens SEC filing in a new tab) After-hours · 16:05 ET Summarise
20 10-Q 10-Q (opens SEC filing in a new tab) After-hours · 16:02 ET Summarise
19 S-3ASR S-3ASR (opens SEC filing in a new tab) After-hours · 16:05 ET Summarise
18 8-K 8-K (opens SEC filing in a new tab) Pre-market · 08:01 ET Summarise
17 8-K 8-K (opens SEC filing in a new tab) After-hours · 16:01 ET Summarise
16 8-K 8-K (opens SEC filing in a new tab) After-hours · 16:45 ET Summarise
15 8-K 8-K (opens SEC filing in a new tab) Pre-market · 08:05 ET Summarise
14 10-Q 10-Q (opens SEC filing in a new tab) Pre-market · 08:00 ET Summarise
13 8-K 8-K (opens SEC filing in a new tab) After-hours · 16:15 ET Summarise
12 424B5 424B5 (opens SEC filing in a new tab) Next filing day · accepted 15 Apr, 17:42 ET Summarise
11 424B5 424B5 (opens SEC filing in a new tab) After-hours · 17:26 ET Summarise
10 8-K 8-K (opens SEC filing in a new tab) After-hours · 16:29 ET Summarise
9 8-K 8-K (opens SEC filing in a new tab) Pre-market · 07:46 ET Summarise
8 DEFA14A DEFA14A (opens SEC filing in a new tab) After-hours · 16:05 ET Summarise
7 DEF 14A DEF 14A (opens SEC filing in a new tab) After-hours · 16:01 ET Summarise
6 8-K 8-K (opens SEC filing in a new tab) After-hours · 16:05 ET Summarise
5 10-K 10-K (opens SEC filing in a new tab) After-hours · 16:01 ET Summarise
4 S-3 S-3 (opens SEC filing in a new tab) After-hours · 16:33 ET Summarise
3 8-K 8-K (opens SEC filing in a new tab) Pre-market · 09:00 ET Summarise
2 8-K 8-K (opens SEC filing in a new tab) After-hours · 16:11 ET Summarise
1 10-Q 10-Q (opens SEC filing in a new tab) After-hours · 16:01 ET Summarise