Upstream Bio, Inc UPB

Open calendar →

Upstream Bio, Inc. - Common Stock · Company · Nasdaq · Healthcare / Biotechnology

Paper trade (simulated — no real money)

Fill: USD 2.7400 · FX 1 USD = 1.277900 SGD · about SGD 3.5014 per unit

Sign in to practise with simulated trades before investing real money. USD fills are converted into the SGD portfolio at the displayed rate.

Announcement types: (default: consequential filings)
Results & current reports
Capital markets
Ownership & governance

USD closing-price chart (daily close from yfinance · Last year)

USD 21.86 → 2.74 · -87.5%
32.60017.6702.740 1,2,3 4,5 6,7,8,9 10,11 12,13 14 15,16 17 Oct 25Jan 26Apr 26Jul 26Oct 26

Numbered dotted lines mark the filtered filings under Announcement Events below.

Price & SEC Filing History 24 Oct 2025 — 25 Oct 2026 (Last year)

Daily Nasdaq prices are sourced from yfinance. Yellow highlighting marks an intraday rise or a gap up between adjacent trading sessions. SEC acceptance times are converted to US Eastern time: pre-market filings appear below that day’s OHLCV row; filings accepted after the 09:30 ET open appear above it. The SEC does not publish an exact first-public-availability timestamp, so acceptance time is the best available proxy.

Weekend
Weekend
2.9500 2.9600 2.6950 2.7400 1,051,216
2.7700 2.9900 2.7000 2.9900 1,450,000
2.8300 2.9750 2.7650 2.8000 1,410,500
2.7900 3.0900 2.7800 2.8200 1,676,000
2.7600 3.0700 2.7500 2.8000 1,603,700
Weekend
Weekend
3.3900 3.3900 2.7400 2.7600 1,836,400
3.4400 3.5550 3.2850 3.3700 1,285,300
3.4750 3.6000 3.2900 3.4200 1,572,500
4.1400 4.1550 3.5200 3.5500 1,037,400
4.6800 4.7200 4.1200 4.1700 848,400
Weekend
Weekend
4.5400 4.7600 4.5100 4.7000 1,187,800
4.5300 4.6500 4.3650 4.5500 2,857,200
4.5500 4.7200 4.5000 4.6100 908,400
4.8400 4.8650 4.5300 4.5900 1,062,300
5.0700 5.1000 4.6650 4.8500 1,010,600
Weekend
Weekend
5.1200 5.2100 4.8600 5.0400 956,500
5.2500 5.3450 4.9800 5.0400 832,400
5.2300 5.4550 5.1450 5.2700 851,200
5.2800 5.3050 4.9900 5.1900 784,200
5.3400 5.3850 5.1200 5.3000 615,400
Weekend
Weekend
5.2000 5.3900 5.0700 5.3600 429,200
5.1900 5.2000 5.0450 5.1700 566,600
5.4800 5.4900 4.9850 5.1900 553,000
5.4400 5.5600 5.3800 5.4900 360,400
5.4200 5.4400 5.2700 5.3650 364,000
Weekend
Weekend
5.3200 5.4100 5.2100 5.3400 1,001,000
5.4400 5.4800 5.2350 5.3100 533,900
5.4900 5.5400 5.2700 5.3300 497,200
5.8100 5.8100 5.4550 5.4800 421,300
5.7500 5.8700 5.7000 5.8100 491,000
Weekend
Weekend
5.8400 5.8400 5.6500 5.7300 501,300
5.8600 5.8600 5.6700 5.7500 562,400
6.1400 6.2000 5.7700 5.9600 726,200
6.0100 6.2100 5.7700 6.1900 949,700
No trading
Weekend
Weekend
6.0000 6.2300 5.9650 6.0100 642,900
6.4900 6.4900 5.7700 6.0800 1,351,800
6.6200 6.9800 6.4100 6.4800 515,400
6.5800 6.7200 6.5000 6.5500 476,500
17 · 8-K Pre-market · 07:05 ET 8-K ↗
6.6400 6.7700 6.4400 6.6200 895,000
Weekend
Weekend
6.7100 6.7900 6.6000 6.6900 445,500
7.1100 7.1400 6.7800 6.7900 335,100
7.1800 7.3100 6.9000 7.1300 432,900
6.6800 7.1800 6.5500 7.1800 554,300
7.0000 7.1100 6.4600 6.6100 538,500
Weekend
Weekend
6.9100 7.0060 6.8500 6.9700 434,200
7.4800 7.5550 6.7450 6.8500 592,900
7.0400 7.5300 6.9100 7.5150 574,100
7.2800 7.4350 6.7300 6.8500 461,600
7.0200 7.1900 6.8600 7.1400 852,400
Weekend
Weekend
6.9500 7.1400 6.8000 7.0700 688,200
7.0200 7.0400 6.8700 6.9100 378,800
7.0000 7.2500 6.8400 6.9100 635,100
7.4800 7.7000 7.0100 7.0900 628,100
16 · 10-Q Pre-market · 07:10 ET 10-Q ↗ 15 · 8-K Pre-market · 07:05 ET 8-K ↗
7.3200 7.6200 7.2000 7.4400 869,600
Weekend
Weekend
6.9400 7.2600 6.8900 7.2500 621,800
6.7500 7.1660 6.6600 6.8700 427,200
6.7700 6.8800 6.5800 6.7400 917,300
6.4000 6.9150 6.4000 6.7900 1,362,500
6.3100 6.4300 6.1750 6.4200 774,300
Weekend
Weekend
6.5800 6.6880 6.2900 6.3100 297,700
6.3500 6.6650 6.2900 6.5700 320,600
6.3900 6.4800 6.2100 6.4100 702,800
6.4000 6.5400 6.0900 6.4000 433,200
6.4700 6.6000 6.2600 6.4000 459,500
Weekend
Weekend
6.4000 6.6100 6.1600 6.4100 626,400
6.4600 6.5900 6.3200 6.4000 626,100
6.9500 6.9900 6.4700 6.5900 704,500
6.9200 7.0800 6.8600 6.9800 341,000
6.9900 7.1450 6.8000 6.9800 458,000
Weekend
Weekend
7.0800 7.3000 6.9000 7.0100 378,000
7.2400 7.3400 6.9800 7.2300 561,200
7.1200 7.3200 7.0800 7.2700 332,100
7.2800 7.3400 7.0000 7.1400 344,700
7.4700 7.5250 7.0200 7.2800 266,100
Weekend
Weekend
7.8100 7.8100 7.2800 7.5300 341,700
7.9800 8.0000 7.5700 7.8100 467,500
7.7300 8.0000 7.5300 7.9800 635,100
7.4800 8.0000 7.3200 7.8600 809,500
7.5000 7.5910 7.3400 7.4000 357,000
Weekend
Weekend
No trading
7.3100 7.7200 7.1640 7.5100 363,200
6.9000 7.4200 6.8100 7.2800 561,000
6.9400 7.3800 6.8800 6.9200 557,800
6.7700 7.0000 6.5600 6.9300 662,700
Weekend
Weekend
6.3600 6.7800 6.3500 6.7500 1,311,200
6.3200 6.5700 6.2800 6.3600 469,900
6.3500 6.7100 6.3200 6.3500 654,600
6.2600 6.5400 6.2400 6.3200 623,900
6.3300 6.6000 6.2500 6.3000 849,200
Weekend
Weekend
No trading
6.2600 6.5200 6.1450 6.2500 829,700
5.9400 6.3300 5.8800 6.1500 839,800
6.1000 6.1850 5.8600 5.9200 519,900
6.1900 6.2800 6.0100 6.1000 681,400
Weekend
Weekend
6.0300 6.4700 5.8500 6.1000 1,432,200
6.2800 6.4000 6.1100 6.3800 833,100
14 · 8-K After-hours · 16:05 ET 8-K ↗
6.6400 6.8010 6.2500 6.2800 450,100
6.5300 6.7800 6.4150 6.6900 500,500
7.1600 7.1600 6.4050 6.4500 783,900
Weekend
Weekend
7.3900 7.4500 6.9800 7.0500 672,400
7.6800 7.7800 7.3000 7.4300 688,200
7.5200 7.8600 7.4000 7.6300 666,400
7.9600 7.9600 7.1850 7.2500 632,600
8.3300 8.6400 7.9900 8.0800 595,100
Weekend
Weekend
8.3100 8.5000 8.1650 8.3600 499,100
8.2400 8.3750 8.1300 8.3200 320,800
8.1900 8.5500 8.1850 8.2600 420,400
8.4400 8.4500 8.1050 8.2100 593,000
No trading
Weekend
Weekend
8.4700 8.6900 8.3300 8.3700 354,400
8.3500 8.5950 8.2500 8.4600 597,500
8.0200 8.5600 7.9900 8.4100 593,000
8.4200 8.6400 8.0200 8.0300 982,500
8.9700 9.1300 8.1240 8.5100 511,300
Weekend
Weekend
8.5900 9.1400 8.5500 9.0900 979,900
9.4500 9.5180 8.5050 8.7900 568,800
8.9600 9.4650 8.8000 9.3600 815,600
13 · 10-Q Pre-market · 07:10 ET 10-Q ↗ 12 · 8-K Pre-market · 07:05 ET 8-K ↗
8.9300 9.1400 8.8300 8.9500 467,500
9.2000 9.5950 9.0500 9.1100 618,900
Weekend
Weekend
8.8800 9.3500 8.8000 9.0900 456,000
9.1400 9.1400 8.6900 8.9850 272,800
9.1600 9.2900 8.9800 9.1900 409,200
9.3100 9.5000 8.8800 9.1200 262,700
9.3400 9.5700 9.1600 9.3100 300,400
Weekend
Weekend
9.2500 9.4100 9.1200 9.4000 489,700
9.2000 9.3000 9.0600 9.1800 395,000
9.3200 9.3700 8.9700 9.1900 415,800
9.3200 9.6450 9.2800 9.5100 474,600
9.2200 9.6350 9.1530 9.2900 664,700
Weekend
Weekend
9.4700 9.6300 9.2100 9.3000 558,800
9.6200 9.7200 9.3800 9.6000 428,000
9.3100 9.7050 9.0600 9.6400 624,800
10.0100 10.0530 9.2200 9.2600 527,000
9.9800 10.0900 9.7900 9.9900 387,900
Weekend
Weekend
10.4500 10.6400 9.8350 9.9900 661,400
11 · DEFA14A After-hours · 16:10 ET DEFA14A ↗ 10 · DEF 14A After-hours · 16:05 ET DEF 14A ↗
9.8800 10.1500 9.6800 10.1000 1,152,800
10.4000 10.5200 9.7900 9.8800 552,100
10.1350 10.4500 10.0770 10.3400 645,900
10.4500 10.6050 10.0900 10.2300 412,500
Weekend
Weekend
10.4800 10.6680 10.3350 10.4900 733,100
9.6700 10.4900 9.6300 10.4200 813,000
9.8700 10.0000 9.4520 9.8400 474,400
9.5900 9.7050 9.3100 9.7000 316,800
9.4900 9.8900 9.3640 9.7200 502,200
Weekend
Weekend
No trading
9.0600 9.6400 8.9650 9.5000 537,600
9.2200 9.3500 8.9600 9.3100 848,800
9.0100 9.1700 8.8200 9.0000 1,034,600
8.5300 8.7800 8.2900 8.7800 863,200
Weekend
Weekend
8.7200 9.1500 8.1000 8.6700 939,900
9 · 8-K After-hours · 17:09 ET 8-K ↗ 8 · 424B5 After-hours · 17:05 ET 424B5 ↗ 7 · 10-K After-hours · 16:04 ET 10-K ↗
9.4800 10.4300 9.3800 9.7900 883,200
6 · 8-K Pre-market · 07:05 ET 8-K ↗
8.6800 9.5700 8.6700 9.4700 687,000
8.3500 8.6200 8.1200 8.4500 747,600
8.7100 9.0300 8.4300 8.4500 743,400
Weekend
Weekend
8.3800 8.6800 8.1630 8.6700 3,024,900
8.4400 8.6300 8.2300 8.3800 734,900
9.5800 9.7000 8.6550 8.6650 719,600
9.5800 9.9000 9.1700 9.7100 914,800
9.2900 9.6750 9.2700 9.6100 722,500
Weekend
Weekend
9.3200 9.7600 8.9300 9.2300 723,100
9.2700 9.4700 8.7000 9.4350 1,135,900
8.1600 9.3700 8.1600 9.3600 1,691,500
8.1500 8.3600 7.9900 8.1200 653,700
7.6500 8.0900 7.6400 8.0600 1,194,300
Weekend
Weekend
7.4700 7.7700 7.4000 7.6600 702,500
7.6400 7.7800 7.4000 7.6700 941,700
7.3700 8.0100 7.3330 7.8000 1,170,500
7.5850 7.6400 7.2500 7.3600 998,200
7.5100 7.9150 7.4600 7.7000 1,672,700
Weekend
Weekend
7.8700 8.0700 7.6200 7.6800 1,436,000
7.7400 8.3170 7.7000 7.9000 1,497,000
7.9000 8.1000 7.7000 7.7400 987,800
8.0500 8.2700 7.7800 7.9200 1,538,700
8.0900 8.3200 7.7400 8.0200 1,625,500
Weekend
Weekend
8.4100 8.6900 8.0100 8.0800 3,594,900
8.3200 8.7270 8.1400 8.5400 1,924,100
8.1800 8.6600 7.9300 8.2900 2,893,200
8.6850 9.0000 7.9600 8.3300 6,026,000
No trading
Weekend
Weekend
12.6900 12.6900 8.5200 8.7500 6,503,600
14.8600 14.8600 12.7500 12.8000 3,879,100
19.0000 20.0100 12.6500 14.6900 8,848,200
5 · 8-K Pre-market · 09:17 ET 8-K ↗ 4 · 8-K Pre-market · 06:38 ET 8-K ↗
26.1000 28.5750 25.9300 27.8100 800,800
26.2400 26.2400 25.1600 26.1200 509,700
Weekend
Weekend
26.5600 27.9800 25.9400 26.2000 517,900
29.4000 30.3100 25.8700 26.0000 619,300
30.8800 30.8800 28.3450 29.3800 610,500
30.3800 31.0500 29.8200 30.7900 635,700
31.1000 32.3810 29.6400 29.9400 783,100
Weekend
Weekend
30.6400 31.3700 29.7100 31.0800 667,500
30.3000 31.1150 29.6100 30.9400 459,600
32.5000 32.5000 29.9900 30.4300 658,100
30.2400 32.8300 30.1300 32.5000 1,068,800
29.7700 30.9100 29.7600 30.1600 545,700
Weekend
Weekend
31.6200 31.6200 29.8250 30.0200 371,100
31.7400 32.5200 31.7040 31.7900 402,500
30.9500 32.1400 30.3100 31.5900 468,400
30.2200 31.5200 29.0800 31.0000 774,100
No trading
Weekend
Weekend
31.0600 31.6400 29.8000 31.0000 418,400
32.4200 32.4200 30.7400 30.9000 718,900
32.6800 33.6800 31.9500 32.3000 621,000
31.7100 32.6600 30.4800 32.6000 834,700
29.7300 31.9300 29.3400 31.6600 679,000
Weekend
Weekend
27.8700 30.6000 27.8700 29.7500 851,400
27.7100 28.4900 27.2150 27.5400 502,700
26.0800 28.1600 26.0800 28.0800 700,300
25.9300 26.5200 25.0000 25.8700 452,800
27.0700 27.3900 25.2500 26.1300 689,800
Weekend
Weekend
27.3000 28.0100 26.7200 27.0700 586,400
No trading
27.1700 27.5800 26.8600 27.1500 517,800
28.7700 28.7700 26.8550 27.3200 831,500
29.4800 29.9200 28.7000 28.8300 238,300
Weekend
Weekend
30.1100 30.1100 29.1000 29.4800 228,000
No trading
29.6500 30.7600 29.6000 30.2700 266,500
30.2700 30.7600 29.0500 29.2100 347,200
29.2900 30.8900 29.0000 30.4300 701,400
Weekend
Weekend
30.0100 30.5600 29.1900 29.3500 1,463,000
29.0900 30.2700 28.3600 29.8600 795,900
29.4100 29.9500 28.1500 28.3300 439,700
26.9200 29.7250 26.0300 29.3200 932,300
27.5600 27.9450 26.6750 27.2000 1,173,500
Weekend
Weekend
28.0000 28.2500 26.7800 27.1400 305,400
28.7200 29.5100 27.1600 27.4700 661,700
28.3700 29.5500 27.9300 28.6700 342,300
28.7300 29.1700 27.9900 28.3650 403,400
28.0300 29.5000 27.9100 28.9700 345,100
Weekend
Weekend
27.8200 28.4250 27.0000 27.7500 399,900
26.6900 28.4500 26.6900 27.7400 568,500
25.0100 27.1500 24.9400 26.9700 497,300
29.6100 29.8900 24.6100 25.0100 839,100
28.3200 29.0800 28.0700 28.9800 418,300
Weekend
Weekend
28.1400 28.8900 28.0600 28.6000 145,000
No trading
29.1200 33.0000 27.8950 28.0000 509,400
26.2200 29.2900 25.8350 28.8300 683,400
25.3500 26.9940 25.3180 26.0500 1,256,800
Weekend
Weekend
24.7100 26.1000 24.1200 25.5500 384,500
25.3700 26.1900 24.7500 24.9600 402,300
25.3100 25.7950 24.1000 24.9400 422,200
26.2000 26.2000 25.0700 25.5600 585,000
24.3900 26.1500 24.1350 25.7000 527,500
Weekend
Weekend
23.0800 25.1000 23.0100 24.5300 801,800
23.5200 23.9900 22.9850 23.3400 429,900
23.7400 24.9500 23.2200 23.7200 476,600
23.3100 24.8000 22.8900 23.7800 215,000
23.5200 23.8700 22.5900 23.5000 490,500
Weekend
Weekend
23.6400 23.6400 21.9800 22.9600 271,700
24.0000 24.5800 23.0300 23.6600 289,400
25.4400 25.6500 23.6620 23.9700 234,600
3 · S-3ASR Pre-market · 07:37 ET S-3ASR ↗ 2 · 10-Q Pre-market · 07:10 ET 10-Q ↗ 1 · 8-K Pre-market · 07:05 ET 8-K ↗
24.2700 25.5650 24.0220 25.0400 342,700
25.9200 26.2200 24.7600 25.0200 316,700
Weekend
Weekend
25.7000 26.2500 25.4800 25.8500 215,100
23.9300 26.9000 23.9300 25.7700 352,900
24.8200 25.3300 23.9500 24.1900 197,900
23.5000 25.0900 23.5000 24.8400 418,000
21.9700 24.0000 21.8900 23.5800 413,900
Weekend
Weekend
21.4500 22.1400 21.4400 21.8600 186,200

Announcement Events

Each title opens the filing on the SEC website. Registered users can summarise the filing and up to seven relevant exhibits linked within the same SEC submission.

17 8-K 8-K (opens SEC filing in a new tab) Pre-market · 07:05 ET Summarise
16 10-Q 10-Q (opens SEC filing in a new tab) Pre-market · 07:10 ET Summarise
15 8-K 8-K (opens SEC filing in a new tab) Pre-market · 07:05 ET Summarise
14 8-K 8-K (opens SEC filing in a new tab) After-hours · 16:05 ET Summarise
13 10-Q 10-Q (opens SEC filing in a new tab) Pre-market · 07:10 ET Summarise
12 8-K 8-K (opens SEC filing in a new tab) Pre-market · 07:05 ET Summarise
11 DEFA14A DEFA14A (opens SEC filing in a new tab) After-hours · 16:10 ET Summarise
10 DEF 14A DEF 14A (opens SEC filing in a new tab) After-hours · 16:05 ET Summarise
9 8-K 8-K (opens SEC filing in a new tab) After-hours · 17:09 ET Summarise
8 424B5 424B5 (opens SEC filing in a new tab) After-hours · 17:05 ET Summarise
7 10-K 10-K (opens SEC filing in a new tab) After-hours · 16:04 ET Summarise
6 8-K 8-K (opens SEC filing in a new tab) Pre-market · 07:05 ET Summarise
5 8-K 8-K (opens SEC filing in a new tab) Pre-market · 09:17 ET Summarise
4 8-K 8-K (opens SEC filing in a new tab) Pre-market · 06:38 ET Summarise
3 S-3ASR S-3ASR (opens SEC filing in a new tab) Pre-market · 07:37 ET Summarise
2 10-Q 10-Q (opens SEC filing in a new tab) Pre-market · 07:10 ET Summarise
1 8-K 8-K (opens SEC filing in a new tab) Pre-market · 07:05 ET Summarise